منابع مشابه
Epigenetics meets endocrinology.
Although genetics determines endocrine phenotypes, it cannot fully explain the great variability and reversibility of the system in response to environmental changes. Evidence now suggests that epigenetics, i.e. heritable but reversible changes in gene function without changes in nucleotide sequence, links genetics and environment in shaping endocrine function. Epigenetic mechanisms, including ...
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Previous work has demonstrated that, besides its effects on Ca and bone metabolism, the active form of cholecalciferol, 1,25-dihydroxycholecalciferol (1,25(OH)2D3), possesses pronounced immunomodulatory effects. In non-obese diabetic (NOD) mice primary (before disease onset), secondary (after insulitis but before diabetes onset) as well as tertiary (after transplantation of syngeneic islets) pr...
متن کاملArabidopsis epigenetics: when RNA meets chromatin.
Recent work in plants and other eukaryotes has uncovered a major role for RNA interference in silent chromatin formation. The heritability of the silent state through multiple cell division cycles and, in some instances, through meiosis is assured by epigenetic marks. In plants, transposable elements and transgenes provide striking examples of the stable inheritance of repressed states, and are...
متن کاملEcology meets endocrinology: environmental sex determination in fishes.
Van Valen (1973) characterized evolution as the control of development by ecology. Sex determination in fishes provides some clear examples of this “control” in operation. Teleost fishes show a remarkable variety of sex determination and differentiation patterns. These range from systems in which sex is determined by sex chromosomes, as in birds and mammals, to simultaneous hermaphrodites that ...
متن کاملWhen Food Meets Man: the Contribution of Epigenetics to Health
Post-translational modifications of chromatin contribute to the epigenetic control of gene transcription. The response to food intake and individual nutrients also includes epigenetic events. Bile acids are necessary for lipid digestion and absorption, and more recently have emerged as signaling molecules. Their synthesis is transcriptionally regulated also in relation to the fasted-to-fed cycl...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2010
ISSN: 0952-5041,1479-6813
DOI: 10.1677/jme-10-0053